Bystander Activation Involving T Lymphocytes in Herpetic Stromal Keratitis

Lymphocytes in Herpetic Stromal Keratitis Bystander Activation Involving T

Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis.

PURPOSE To investigate the effect of human amniotic membrane transplantation (AMT) on T-cell immune response in murine corneas with herpetic stromal keratitis (HSK). METHODS Herpes simplex virus (HSV)-1-infected BALB/c mice with necrotizing HSK were treated with AMT. CD3(+) cell apoptosis was determined in treated corneas and in vitro by flow cytometric analysis using the annexin V/7-AAD syst...

Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty

This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etio...

Effectiveness of levamisole on stromal herpetic keratitis.

Stromal herpetic keratitis has a poor prognosis. To date, corticosteroids appear to be the most efficatious agents against the condition. However, corticosteroids are immuno6uppresive, and may cause recurrences. The recent findings of decreased cellular immunity in the condition offer the possibility of using levamisole as the therapeutic agent. The present investigation was undertaken to evalu...

Nonspecific mitogen responses of peripheral lymphocytes in levamisole-treated patients with herpetic stromal keratitis.

For the purpose of determining the effect of levamisole on cell-mediated immunity of patients with herpetic stromal keratitis, the response of peripheral lymphocytes to three mitogens (PHA, Con A and PWM) was examined in a total of 19 cases of herpetic stromal keratitis (16 effective cases) including 12 patients undergoing levamisole administration. As controls, a similar study was made on 35 h...